The IL-11 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to IL-11, IL11, and Interleukin 11. This antibody recognizes Human antigen. The IL-11 Antibody has been validated for the following applications: ELISA, Immunocytochemistry, and Western Blot.
Description
Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4)